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Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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September 12, 2019
DOI:
1Department of Molecular and Cellular Physiology,Albany Medical College, 2The IBD Center, Division of Gastroenterology, Department of Medicine,Albany Medical College, 3Department of Geriatrics, School of Medicine and Health Science,University of North Dakota, 4Department of Neuroscience and Experimental Therapeutics,Albany Medical College
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In this study, we describe a detailed procedure of TNBS-mediated intestinal fibrosis, which exhibits comparable pathophysiology to Crohn's fibrosis. We also discuss this approach in light of rapamycin facilitated inhibitory effects on intestinal fibrosis.
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Mathur, R., Alam, M. M., Zhao, X., Huang, Y., Zhu, X. Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin. J. Vis. Exp. (151), e60067, doi:10.3791/60067 (2019).
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