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Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice
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JoVE Revista Biología del desarrollo
Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

DOI:
10.3791/59966-v

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07:48 min

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September 16, 2019

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, , ,
1Graduate Program in Cellular and Molecular Medicine,Johns Hopkins University School of Medicine, 2Department of Neurology,Johns Hopkins University School of Medicine, 3Kennedy Krieger Institute, 4Department of Neuroscience,Johns Hopkins University School of Medicine

Capítulos

  • 00:04Título
  • 00:35Surgical Preparation
  • 01:48Xenograft Surgery
  • 03:52Xenograft Harvest
  • 05:43Results: Representative Human Skeletal Muscle Xenograft Analyses
  • 07:12Conclusion

Summary

Traducción Automática

Traducción Automática

Complex human diseases can be challenging to model in traditional laboratory model systems. Here, we describe a surgical approach to model human muscle disease through the transplantation of human skeletal muscle biopsies into immunodeficient mice.

Tags

Keywords: Human Skeletal Muscle XenograftsImmunodeficient MiceMuscle Disease ModelingPreclinical Therapeutic TestingHuman Muscle Cell BiologyRare Or Acquired Muscle DiseasesMuscle BiopsyNOD-Rag-gamma MouseTibialis AnteriorExtensor Digitorum LongusPeroneus LongusSurgical Procedure

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