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Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
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Bioingeniería
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JoVE Revista Bioingeniería
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

12,112 Views

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10:38 min

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January 15, 2018

DOI:

10.3791/56760-v

DOI:
10.3791/56760-v

•

10:38 min
January 15, 2018

•

2 Views
, , , ,
1Department of Chemical Engineering,Northeastern University, 2Nanomedicine Science and Technology Center,Northeastern University, 3Department of Physics,Northeastern University, 4Departments of Bioengineering,Northeastern University, 5Department of Neuroscience,Albert Einstein College of Medicine

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We describe a method of synthesizing biocompatible 10-nm gold nanoparticles, functionalized by coating poly-ethylene glycol onto the surface. These particles can be used in vitro and in vivo for delivering therapeutics to nanoscale cellular and extracellular spaces that are difficult to access with conventional nanoparticle sizes.

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Cheng, M. J., Prabakaran, P., Kumar, R., Sridhar, S., Ebong, E. E. Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery. J. Vis. Exp. (131), e56760, doi:10.3791/56760 (2018).

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