We describe here a protocol for microinjection in the rodent brain that uses quartz needles. These needles do not produce detectable tissue damage and ensure reliable delivery even in deep regions. Moreover, they can be adapted to research needs by personalized designs and can be re-used.
Paolone, G., Falcicchia, C., Verlengia, G., Barbieri, M., Binaschi, A., Paliotto, F., Paradiso, B., Soukupova, M., Zucchini, S., Simonato, M. Personalized Needles for Microinjections in the Rodent Brain. J. Vis. Exp. (131), e55751, doi:10.3791/55751 (2018).