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源自iPSC的人脑组织体的一代新型早期神经发育障碍
JoVE Revista
Biología del desarrollo
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JoVE Revista Biología del desarrollo
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

源自iPSC的人脑组织体的一代新型早期神经发育障碍

DOI:

07:40 min

April 14, 2017

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Capítulos

  • 00:05Título
  • 00:49Embedding Neurospheres in EHS Matrix
  • 01:57Organoids in a Rotary Suspension Culture
  • 03:08Analysis of Brain Organoids
  • 05:47Results: Immunofluorescent Imaging of Cryosectioned Organoids
  • 06:48Conclusion

Summary

Traducción Automática

Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.

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