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门静脉注射模型来研究肝转移乳腺癌
JoVE Revista
Investigación sobre el cáncer
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JoVE Revista Investigación sobre el cáncer
A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
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门静脉注射模型来研究肝转移乳腺癌

39,246 Views

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07:35 min

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December 26, 2016

DOI:

10.3791/54903-v

DOI:
10.3791/54903-v

•

07:35 min
December 26, 2016

•

52 Views
, ,
1Department of Cell, Developmental and Cancer Biology,Oregon Health and Science University

Summary

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A surgical procedure was developed to deliver mammary tumor cells to the murine liver via portal vein injection. This model permits investigation of late stages of liver metastasis in a fully immune competent host, including tumor cell extravasation, seeding, survival, and metastatic outgrowth in the liver.

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Portal Vein InjectionLiver MetastasisBreast CancerTumor CellsMurine ModelMetastatic CascadeCell ExtravasationCell SeedingCell DeathCell ProliferationCell DormancySurgical ProcedureAnatomical SurveillanceBalb/c MiceAnalgesiaDisinfectionIncisionTumor Cell Injection

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Cite this Article

Goddard, E. T., Fischer, J., Schedin, P. A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer. J. Vis. Exp. (118), e54903, doi:10.3791/54903 (2016).

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