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JoVE Journal Neuroscience
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
 

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Article DOI: 10.3791/52919-v • 07:43 min • May 12th, 2015
May 12th, 2015 •
1, 1, 2, 2, 1,2
1Centre for Integrative Biology (CIBIO), University of Trento, 2CNR Neuroscience Institute, Pisa, Italy

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Resumen
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We describe an immunohistochemistry protocol to study the profile of hippocampal neuron activation following exposure to a spatial learning task in a mouse model characterized by cognitive deficits of neurodevelopmental origin. This protocol can be applied to both genetic or pharmacological mouse models characterized by cognitive deficits.

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Immunohistochemical Visualization Hippocampal Neuron Activity Spatial Learning Mouse Model Neurodevelopmental Disorders Phosphorylated Extracellular-regulated Kinase (pERK) Cognitive Deficits Engrailed-2 Knockout (En2-/-) Mice Autism Spectrum Disorders (ASD) Morris Water Maze (MWM) Wild-type (WT) Controls Hippocampal Subfields Genetic Mouse Models Pharmacological Mouse Models
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