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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

DOI:
10.3791/52409-v

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06:38 min

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March 11, 2016

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, , ,
1Cardiac Muscle Research Laboratory, Cardiovascular Division,Brigham and Women’s Hospital, Harvard Medical School, 2Renal Division,Brigham and Women’s Hospital, Harvard Medical School

Capítulos

  • 00:05Título
  • 01:28Nephrotoxicity Rat Model and Transverse Imaging of Kidney
  • 03:56Nephrotoxicity Induction using Cisplatin
  • 04:31Results: Creatinine, Histology and Ultrasound Images after Cisplatin Treatment
  • 05:53Conclusion

Summary

Traducción Automática

Traducción Automática

Early stage hemodynamic dysfunction is critical to the development of kidney disease. Yet, detection methodologies are limited. Recent advances in sonography provide a noninvasive, accurate option for early detection of kidney injury. This study outlines a step-by-step, sonographic methodology for detecting kidney dysfunction using a drug-induced nephrotoxicity rat model.

Tags

Keywords: Sonographic MethodologyKidney DysfunctionDrug-induced NephrotoxicityRat ModelUltrasound ImagingRenal HemodynamicsCisplatin-induced Acute Kidney InjuryRenal Function MonitoringRenal Hemodynamic ChangesMouse ModelsHigh-resolution UltrasoundRenal ArteryRenal VeinColor DopplerPulsed Wave

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