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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
JoVE 杂志
医学
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JoVE 杂志 医学
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

11,688 Views

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06:38 min

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March 11, 2016

DOI:

10.3791/52409-v

DOI:
10.3791/52409-v

•

06:38 min
March 11, 2016

•

3 Views
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1Cardiac Muscle Research Laboratory, Cardiovascular Division,Brigham and Women’s Hospital, Harvard Medical School, 2Renal Division,Brigham and Women’s Hospital, Harvard Medical School

Summary

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Early stage hemodynamic dysfunction is critical to the development of kidney disease. Yet, detection methodologies are limited. Recent advances in sonography provide a noninvasive, accurate option for early detection of kidney injury. This study outlines a step-by-step, sonographic methodology for detecting kidney dysfunction using a drug-induced nephrotoxicity rat model.

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Fisch, S., Liao, R., Hsiao, L., Lu, T. Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats. J. Vis. Exp. (109), e52409, doi:10.3791/52409 (2016).

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