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JoVE Journal Behavior
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
 

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Article DOI: 10.3791/51484-v • 13:08 min • December 2nd, 2015
December 2nd, 2015 •
1,2, 1,3, 1,2, 1,3, 2, 1, 1, 1,2
1Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, 2Duke-UNC Brain Imaging and Analysis Center, Duke University Medical Center, 3Curriculum in Neurobiology, University of North Carolina at Chapel Hill

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This paper describes how to use the emotional oddball task and fMRI to measure brain activation in children and adolescents at familial high risk for schizophrenia (FHR). FMRI was used to measure differences in fronto-striato-limbic regions during an emotional oddball task. Children with FHR exhibited abnormal functional activation during adolescence.

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Fronto-limbic Activity Emotional Oddball Task Children Familial High Risk For Schizophrenia Adolescence Cognitive Changes Emotional Changes Neurological Changes Functional Magnetic Resonance Imaging (fMRI) Frontal Regions Striatal Regions Limbic Regions Selective Attention Task-irrelevant Emotional Information Aversive Distractors Neutral Distractors Executive Processing Age-appropriate Task Design FMRI Registration Neural Activity Measurement
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