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Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
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Medicina
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JoVE Revista Medicina
Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases

Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases

17,859 Views

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10:59 min

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November 18, 2013

DOI:

10.3791/50957-v

DOI:
10.3791/50957-v

•

10:59 min
November 18, 2013

•

6 Views
, , , , , ,
1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine,University of Michigan Medical Center, 2Department of Molecular Pathology,University of Yamanashi

Summary

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Recent development in gene targeting tools makes production of knockout (KO) rabbits possible. In the present work, we generated five Apolipoprotein (Apo) C-III KO rabbits using Zinc Finger Nucleases (ZFN). This work demonstrated that ZFN is a highly efficient method to produce KO rabbits.

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Cite this Article

Yang, D., Zhang, J., Xu, J., Zhu, T., Fan, Y., Fan, J., Chen, Y. E. Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases. J. Vis. Exp. (81), e50957, doi:10.3791/50957 (2013).

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