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Journal / Medicine / Production of Apolipoprotein C-III Knockout…
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Medicine

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JoVE Journal Medicine
Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
 

Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases

Article DOI: 10.3791/50957-v • 10:59 min • November 18th, 2013
November 18th, 2013 •
1, 1, 1, 1, 1, 2, 1
1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Department of Molecular Pathology, University of Yamanashi

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Summary
Automatic Translation

Recent development in gene targeting tools makes production of knockout (KO) rabbits possible. In the present work, we generated five Apolipoprotein (Apo) C-III KO rabbits using Zinc Finger Nucleases (ZFN). This work demonstrated that ZFN is a highly efficient method to produce KO rabbits.

Tags

Apolipoprotein C-III Knockout Rabbits Zinc Finger Nucleases Plasma Chylomicron Very Low Density Lipoprotein High Density Lipoproteins Cardiovascular Diseases Insulin Resistance Obesity Hypertriglyceridemia Lipid Metabolisms Transgenic Mouse Models ApoCIII Knockout Mice Lipoprotein Metabolism Atherogenic ApoCIII KO Rabbits Human Lipid Metabolism Atherosclerosis Zinc Finger Nuclease Sets Embryo Microinjection Mutation Rates
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