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Immunology and Infection

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JoVE Journal Immunology and Infection
Assays til identifikation af nye Antivirale mod bluetonguevirus
 
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Assays til identifikation af nye Antivirale mod bluetonguevirus

Article DOI: 10.3791/50820-v • 12:02 min • October 11th, 2013
October 11th, 2013 •
1, 2, 1
1Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, 2Molette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry, Auburn University

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Tre assays, herunder cytopatisk effekt (CPE)-baserede assay, dosis-respons analyse og Time-of-Addition (ToA) assay er blevet udviklet, optimeret, valideret og udnyttet til at identificere nye antivirale mod bluetongue-virus (BTV), samt at bestemme mulig mekanisme-of-aktion (Landbrugsministeriet) for nyligt identificerede antivirale lægemidler.

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Immunologi Drug Discovery Drug Evaluation prækliniske evalueringer som emne Drug Evaluation forundersøgelser Biologisk Assay teknologi Pharmaceutical højkapacitetsscreening Analyser dyresygdomme Efterforskningsteknik antiviral Effekt bluetonguevirus cytopatisk effekt Dosisrespons Time-of-Addition Mekanisme-of-aktion
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