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Visualization of the Interstitial Cells of Cajal (ICC) Network in Mice
 

Visualization of the Interstitial Cells of Cajal (ICC) Network in Mice

Article DOI: 10.3791/2802-v • 09:46 min • July 27th, 2011
July 27th, 2011 •
1,2, 2, 3, 3, 2,4, 1,5
1Department of Medicine, Memorial Sloan Kettering Cancer Center, 2Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 3Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 4Howard Hughes, Medical Institute, 5Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University

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Resumen
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The interstitial cells of Cajal (ICC) are the pacemaker cells of the gastrointestinal (GI) tract. They form complex networks between smooth muscle cells and post-ganglionic neuronal fibers to regulate GI contractility. Here, we present immunofluorescence methods cross-sectional and whole-mount visualization of murine ICC networks.

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Visualization Interstitial Cells Of Cajal (ICC) Mice Gastrointestinal (GI) Tract Pacemaker Cells Slow Waves Peristalsis Enteric Nervous System Motility Disorders KIT Receptor Tyrosine Kinase KIT Immunostaining ICC Network KIT Activity Neoplastic Transformation Gastrointestinal Stromal Tumor (GIST) ETV1 Survival Factor ICC/GIST Lineage Tumorigenesis Activating KIT Mutations Visualization Methods Previously Published Protocols Anoctamin 1 (ANO1) Membrane Marker Immunofluorescence
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