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Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
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Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
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July 29, 2021
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The most notable symptom of migraine is severe head pain, and it is hypothesized that this is mediated by sensory neurons innervating the meninges. Here, we present a method to locally apply substances to the dura in a minimally invasive manner while using facial hypersensitivity as an output.
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Mason, B. N., Avona, A., Lackovic, J., Dussor, G. Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache. J. Vis. Exp. (173), e62867, doi:10.3791/62867 (2021).
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