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1Department of Neurology, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430000, China, 2Key Laboratory of Neurological Diseases of Chinese Ministry of Education, The School of Basic Medicine, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430000,China, 3Department of Pharmacology, School of Basic Medical Science; State Key Laboratory of Medical Neurobiology,Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China
Kapitel
- 00:04Introduction
- 01:06Mouse Screening Preparation
- 01:58Chronic Sleep Fragmentation (CSF) Modeling
- 03:04Morris Water Maze (MWM) Test
- 04:00Results: Representative Effects of CSF Modeling on Young Wild-Type Mouse Cognitive Abilities and Anxiety-Like Behaviors
- 05:34Conclusion
Apresentado aqui é um protocolo para fragmentação crônica do sono (CSF) modelo alcançado por um rotor orbital eletricamente controlado, que poderia induzir déficit cognitivo confirmado e comportamento semelhante à ansiedade em camundongos jovens do tipo selvagem. Este modelo pode ser aplicado para explorar a patogênese da perturbação crônica do sono e distúrbios relacionados.
