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Neuroscience

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JoVE Journal Neuroscience
A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
 

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Article DOI: 10.3791/61269-v • 08:02 min • July 16th, 2020
July 16th, 2020 •
*1,2, *2, 2, 3, 1,2, 2, 1,2, 1,2, 3
1Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology, Cancer Center Amsterdam, 2Princess Máxima Center for Pediatric Oncology, 3Imaging Division, Utrecht University
* These authors contributed equally

Summary
Automatic Translation

The blood-brain barrier (BBB) can be temporarily disrupted with microbubble-mediated focused ultrasound (FUS). Here, we describe a step-by-step protocol for high-throughput BBB opening in vivo using a modular FUS system accessible for non-ultrasound experts.

Tags

High-throughput Image-guided Stereotactic Neuronavigation Focused Ultrasound System Blood-brain Barrier Opening Rodents High-grade Gliomas Diffused Intrinsic Pontine Glioma Invasive Tumors Mortality Chemotherapy Effective Treatments Neuro-navigated Cost-effective Preclinical Drug Evaluation Studies Precision Medicine Right Drug Right Dose Right Patient Right Time Preselected Drugs Screening Compact High-throughput Focused Ultrasound System Image-guided Stereotactic Neuro-navigation Focused Ultrasound Procedure
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