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A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
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JoVE Journal Neurowissenschaften
A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

DOI:
10.3791/61269-v

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08:02 min

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July 16, 2020

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, , , , , , , ,
1Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology,Cancer Center Amsterdam, 2Princess Máxima Center for Pediatric Oncology, 3Imaging Division,Utrecht University

Summary

Automatische Übersetzung

Automatische Übersetzung

The blood-brain barrier (BBB) can be temporarily disrupted with microbubble-mediated focused ultrasound (FUS). Here, we describe a step-by-step protocol for high-throughput BBB opening in vivo using a modular FUS system accessible for non-ultrasound experts.

Tags

High-throughputImage-guidedStereotacticNeuronavigationFocused UltrasoundBlood-brain BarrierGliomaPrecision MedicineDrug EvaluationSonoporationTransducerStereotactic PlatformAnimal Preparation

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