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人体血液的突变载荷和克隆成分的特征

JoVE Journal
Genetik

This content is Free Access.

JoVE Journal Genetik

Characterizing Mutational Load and Clonal Composition of Human Blood

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人体血液的突变载荷和克隆成分的特征

7,039 Views

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07:58 min

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July 11, 2019

DOI:

10.3791/59846-v

DOI:

10.3791/59846-v

•

07:58 min

July 11, 2019

•

3 Views

Axel Rosendahl Huber¹, Freek Manders¹, Rurika Oka¹, Ruben van Boxtel¹

¹Princess Máxima Center for Pediatric Oncology

Summary

细胞体突变模式反映先前突变暴露,可以揭示发育系系关系。这里介绍的是一种对单个造血干细胞和祖细胞的体细胞突变进行编目和分析的方法。

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