Measuring Neuromuscular Junction Functionality

Emanuele Rizzuto; Simona Pisu; Carmine Nicoletti; Zaccaria Del Prete; Antonio Musar&#242;

doi:10.3791/55227

Journal

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Neurowissenschaften

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Measuring Neuromuscular Junction Functionality

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Neurowissenschaften
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JoVE Journal Neurowissenschaften

Measuring Neuromuscular Junction Functionality

17,625 Views

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10:40 min

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August 06, 2017

DOI:

10.3791/55227-v

DOI:

10.3791/55227-v

•

10:40 min

August 06, 2017

•

21 Views

Emanuele Rizzuto¹, Simona Pisu², Carmine Nicoletti², Zaccaria Del Prete^1,3, Antonio Musarò^2,3

¹Department of Mechanical and Aerospace Engineering,Sapienza University of Rome, ²Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology,Sapienza University of Rome, ³Center for Life Nano Science@Sapienza,Istituto Italiano di Tecnologia

Summary

A functional assessment of the neuromuscular junction (NMJ) can provide essential information on the communication between muscle and nerve. Here we describe a protocol to comprehensively evaluate both the NMJ and muscle functionality using two different muscle-nerve preparations, i.e. soleus-sciatic and diaphragm-phrenic.

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Measuring Neuromuscular Junction Functionality

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