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마우스 모델을 사용하여 급성 이온화 방사선 유발 피부 독성의 정량적 평가를위한 광학 분광학 확산
JoVE Journal
Medizin
This content is Free Access.
JoVE Journal Medizin
Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
Please note that all translations are automatically generated. Click here for the English version.

마우스 모델을 사용하여 급성 이온화 방사선 유발 피부 독성의 정량적 평가를위한 광학 분광학 확산

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06:21 min

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May 27, 2016

DOI:

10.3791/53573-v

DOI:
10.3791/53573-v

•

06:21 min
May 27, 2016

•

3 Views
, , , , , ,
1Department of Radiation Oncology,University of Toronto, 2Department of Physics,Ryerson University, 3Department of Medical Biophysics,University of Toronto, 4Ontario Cancer Institute / Campbell Family Institute for Cancer Research

Summary

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We present a diffuse optical spectroscopic (DOS) approach that provides quantitative optical biomarkers of skin response to radiation. We describe DOS instrumentation design, optical parameters extraction algorithms and the animal handling procedures required to yield representative data from a pre-clinical mouse model of radiation induced erythema.

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Cite this Article

Chin, L., Korpela, E., Kim, A., Yohan, D., Niu, C., Wilson, B. C., Liu, S. K. Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model. J. Vis. Exp. (111), e53573, doi:10.3791/53573 (2016).

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