Modellierung Astrozytom Pathogenese<em> In-vitro-</em> Und<em> In Vivo</em> Verwenden kortikale Astrozyten oder neuralen Stammzellen aus dem Bedingten, gentechnisch veränderte Mäuse
Modellierung Astrozytom Pathogenese<em> In-vitro-</em> Und<em> In Vivo</em> Verwenden kortikale Astrozyten oder neuralen Stammzellen aus dem Bedingten, gentechnisch veränderte Mäuse
Phenotypically wild-type astrocytes and neural stem cells harvested from mice engineered with floxed, conditional oncogenic alleles and transformed via viral Cre-mediated recombination can be used to model astrocytoma pathogenesis in vitro and in vivo by orthotopic injection of transformed cells into brains of syngeneic, immune-competent littermates.