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Controlling Parkinson’s Disease With Adaptive Deep Brain Stimulation
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Medizin
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JoVE Journal Medizin
Controlling Parkinson’s Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson’s Disease With Adaptive Deep Brain Stimulation

21,798 Views

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11:12 min

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July 16, 2014

DOI:

10.3791/51403-v

DOI:
10.3791/51403-v

•

11:12 min
July 16, 2014

•

11 Views
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1Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital,University of Oxford, 2Sobell Department of Motor Neuroscience & Movement Disorders, Unit of Functional Neurosurgery,UCL Institute of Neurology

Summary

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Adaptive deep brain stimulation (aDBS) is effective for Parkinson’s disease, improving symptoms and reducing power consumption compared to conventional deep brain stimulation (cDBS). In aDBS we track a local field potential biomarker (beta oscillatory amplitude) in real time and use this to control the timing of stimulation.

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Parkinson’s DiseaseAdaptive Deep Brain StimulationADBSSubthalamic NucleusBeta AmplitudeReal-time OptimizationMotor FunctionUPDRSPower ConsumptionChronic Stimulation

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Little, S., Pogosyan, A., Neal, S., Zrinzo, L., Hariz, M., Foltynie, T., Limousin, P., Brown, P. Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation. J. Vis. Exp. (89), e51403, doi:10.3791/51403 (2014).

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