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Assessment of Sensorimotor Function in Mouse Models of Parkinson’s Disease
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JoVE Journal Verhalten
Assessment of Sensorimotor Function in Mouse Models of Parkinson’s Disease

Assessment of Sensorimotor Function in Mouse Models of Parkinson’s Disease

54,316 Views

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10:32 min

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June 17, 2013

DOI:

10.3791/50303-v

DOI:
10.3791/50303-v

•

10:32 min
June 17, 2013

•

16 Views
, ,
1Department of Psychology,University of Cincinnati, 2Department of Neurology,University of Cincinnati

Summary

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In Parkinson's disease and movement disorders in general, sensitive and reliable behavioral assays are essential for testing novel potential therapeutics. Here, we describe a manageable battery of sensorimotor tests for mice that are sensitive to varying degrees of injury to the nigrostriatal system and useful for preclinical studies.

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Sensorimotor FunctionMouse ModelsParkinson’s DiseaseBehavioral Outcome MeasuresPreclinical TrialsNigrostriatal DysfunctionSensorimotor TestsGenetic Mouse ModelsDisease-modifying Therapies

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Fleming, S. M., Ekhator, O. R., Ghisays, V. Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease. J. Vis. Exp. (76), e50303, doi:10.3791/50303 (2013).

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