Journal
/
Medizin
/
O Uso de desafio-Farmacológicas fMRI em pesquisa pré-clínica: aplicação ao sistema 5-HT
JoVE Journal
Medizin
This content is Free Access.
JoVE Journal Medizin
The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System

O Uso de desafio-Farmacológicas fMRI em pesquisa pré-clínica: aplicação ao sistema 5-HT

15,143 Views

•

11:27 min

•

April 25, 2012

DOI:

10.3791/3956-v

DOI:
10.3791/3956-v

•

11:27 min
April 25, 2012

•

1 Views
, , , ,
1Department of Radiology, Brain Imaging Center,Academic Medical Center Amsterdam, 2Biological Imaging Centre, MRC Clinical Sciences Centre,Imperial College London

Summary

Automatically generated

O objetivo desta técnica é avaliar a função da serotonina neurotransmissora (5-HT) no animal vivo e respirando sem a ressonância magnética farmacológica (phMRI) e um desafio intravenoso com um inibidor seletivo da recaptação da serotonina (ISRS), a fluoxetina.

Explore More Videos

Pharmacological-challenge FMRIPre-clinical Research5-HT SystemNeurobiological MechanismsDrug ActionNeurotransmitter-related DisordersDepressionADHDImaging MethodsPETSPECTCTBrain DisordersNeuronal ConnectivityClinical InvestigationsMolecular Imaging StrategiesSpatial ResolutionContrast-agentRadio-labeled MoleculesIonizing RadiationsFunctional MRIPsycho-motor TaskAdaptation Of FMRISpecific Neurotransmitter SystemSerotonin (5-HT)Physiological ConditionsPathological Conditions

Read Article

Cite this Article

Klomp, A., Tremoleda, J. L., Schrantee, A., Gsell, W., Reneman, L. The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System. J. Vis. Exp. (62), e3956, doi:10.3791/3956 (2012).

Download .ris file

Copy

Share Video

.

Copy