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L'uso di Farmacologiche-sfida fMRI in ricerca pre-clinica: Applicazione del sistema 5-HT
JoVE Journal
Medizin
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JoVE Journal Medizin
The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
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L'uso di Farmacologiche-sfida fMRI in ricerca pre-clinica: Applicazione del sistema 5-HT

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11:27 min

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April 25, 2012

DOI:

10.3791/3956-v

DOI:
10.3791/3956-v

•

11:27 min
April 25, 2012

•

1 Views
, , , ,
1Department of Radiology, Brain Imaging Center,Academic Medical Center Amsterdam, 2Biological Imaging Centre, MRC Clinical Sciences Centre,Imperial College London

Summary

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L'obiettivo di questa tecnica è quello di valutare serotonina (5-HT) in funzione di neurotrasmettitore l'animale vivo e respiro libero con farmacologica risonanza magnetica (phMRI) e una sfida per via endovenosa con un inibitore selettivo della ricaptazione della serotonina (SSRI), fluoxetina.

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Klomp, A., Tremoleda, J. L., Schrantee, A., Gsell, W., Reneman, L. The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System. J. Vis. Exp. (62), e3956, doi:10.3791/3956 (2012).

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