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Verimli HLA-Ig Tabanlı Yapay antijen sunan hücrelerin Ex vivo Genleşme
JoVE Journal
Immunologie und Infektion
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JoVE Journal Immunologie und Infektion
HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
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Verimli HLA-Ig Tabanlı Yapay antijen sunan hücrelerin Ex vivo Genleşme

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07:18 min

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April 11, 2011

DOI:

10.3791/2801-v

DOI:
10.3791/2801-v

•

07:18 min
April 11, 2011

•

3 Views
, ,
1Immunology Graduate Program,Johns Hopkins University, 2Department of Internal Medicine,Far-Eastern Memorial Hospital, 3Department of Pathology,Johns Hopkins University, 4Institute of Cell Engineering,Johns Hopkins University

Summary

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Antijen-spesifik T hücrelerinin indüksiyon ve genişleme için yeni bir DC bağımsız bir yöntem açıklanmıştır. HLA-A2-Ig tabanlı yapay Antijen sunan hücreler (aAPC), HLA-A2 verimli farklı antijen özgüllüğü CTL genişletmek için kısıtlı peptitler ile yüklenir. Bu teknoloji tabanlı CTL evlatlık immünoterapi için büyük bir potansiyele sahiptir.

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Chiu, Y., Schneck, J. P., Oelke, M. HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL. J. Vis. Exp. (50), e2801, doi:10.3791/2801 (2011).

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