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在免疫缺陷小鼠的建立和传播人类视网膜母细胞瘤肿瘤

JoVE Journal
Medizin

This content is Free Access.

JoVE Journal Medizin

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

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在免疫缺陷小鼠的建立和传播人类视网膜母细胞瘤肿瘤

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07:55 min

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August 04, 2011

DOI:

DOI:

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07:55 min

August 04, 2011

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9 Views

Wesley S. Bond^1,2, Lalita Wadhwa^2,3, Laszlo Perlaky^2,3, Rebecca L. Penland⁴, Mary Y. Hurwitz^2,3, Richard L. Hurwitz*^2,3,5,6, Patricia Chèvez-Barrios*^4,5,7

¹Interdepartmental Program in Translational Biology & Molecular Medicine,Baylor College of Medicine, ²Texas Children's Cancer Center,Baylor College of Medicine, ³Department of Pediatrics,Baylor College of Medicine, ⁴Department of Pathology,The Methodist Hospital Research Institute, ⁵Department of Ophthalmology,Retinoblastoma Center of Houston, ⁶Baylor College of Medicine,Center for Cell and Gene Therapy, ⁷Center for Cell and Gene Therapy,Baylor College of Medicine

Summary

描述的方法传播人类视网膜母细胞瘤小鼠的肿瘤。肿瘤细胞直接注入免疫缺陷小鼠的眼睛。继发性肿瘤已成功地建立了使用直接从人类肿瘤和培养tumorspheres收获细胞。

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