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Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
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Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
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April 14, 2011
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A concurrent infection with influenza A virus is one of the factors implicated in the induction of invasive pneumococcal disease during asymptomatic Streptococcus pneumoniae carriage. Here we describe a mixed infection method using infant mice to investigate the synergism between these two respiratory pathogens.
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Bioluminescent ImagingSynergismStreptococcus PneumoniaeInfluenza A VirusInfant Mice1918 Influenza PandemicSecondary Bacterial InfectionPneumococcus1957 Asian Influenza PandemicSeasonal OutbreaksMorbidityConcurrent InfectionMurine ModelInfluenza Virus InfectionS. Pneumoniae ColonizationKineticsIn Vivo Imaging
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Short, K. R., Diavatopoulos, D. A., Reading, P. C., Brown, L. E., Rogers, K. L., Strugnell, R. A., Wijburg, O. L. Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice. J. Vis. Exp. (50), e2357, doi:10.3791/2357 (2011).
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