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Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices
JoVE 杂志
神经科学
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JoVE 杂志 神经科学
Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

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10:48 min

September 07, 2021

DOI:

10:48 min
September 07, 2021

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Summary

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We describe a method to generate human motor units in commercially available microfluidic devices by co-culturing human induced pluripotent stem cell-derived motor neurons with human primary mesoangioblast-derived myotubes resulting in the formation of functionally active neuromuscular junctions.

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