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Bioengineering

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JoVE Journal Bioengineering
Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
 

Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry

Article DOI: 10.3791/61703-v • 07:28 min • October 29th, 2020
October 29th, 2020 •
*1,2, *1,2, 1,2, 1,2
1Helmholtz Institute for Pharmaceutical Research Saarland, Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmacy, Saarland University, 2Partner Site Hannover-Braunschweig, German Centre for Infection Research (DZIF)
* These authors contributed equally

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The elucidation of the mode-of-action of a novel antibiotic is a challenging task in the drug discovery process. The goal of the method described here is the application of isothermal microcalorimetry using calScreener in antibacterial profiling to provide additional insight into drug-microbe interactions.

Tags

Metabolic Profiling Bactericidal Bacteriostatic Natural Products Isothermal Microcalorimetry Mode Of Action Antibacterial Compounds Real-time Observation Noninvasive Manner Sample Analysis Microbiological Techniques Data Analysis Spectrophotometer Optical Density Colony Forming Units MHB Medium Concentration Antibiotic Concentration Vortexing Inserts Plastic Inserts 48-well Plate Titanium Vials Holders
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