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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
JoVE 杂志
生物工程
This content is Free Access.
JoVE 杂志 生物工程
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

DOI:
10.3791/58757-v

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10:12 min

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January 07, 2019

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, , , ,
1Department of Chemical and Biological Engineering,Princeton University

Chapters

  • 00:04Title
  • 00:51Encapsulation of Hydrophobic Compounds in Polymeric Nanoparticles (NPs) Using a Confined Impinging Jet (CIJ) Mixer
  • 04:08Encapsulation of Ovalbumin in Inverted NPs Using a Small-Scale Multi-Inlet Vortex Mixer (MIVM)
  • 06:44Modifications for Larger-Scale Formulation
  • 07:33Results: Flash NanoPrecipitation (FNP) of Polymeric Nanoparticles with Hydrophobic and Hydrophilic Cores
  • 09:08Conclusion

Summary

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Flash NanoPrecipitation (FNP) is a scalable approach to produce polymeric core-shell nanoparticles. Lab-scale formulations for the encapsulation of hydrophobic or hydrophilic therapeutics are described.

Tags

Flash NanoprecipitationIFNPInverse Flash NanoprecipitationPolymeric NanoparticlesHydrophobic CompoundsHydrophilic CompoundsCIJ MixerSyringe PumpsAnti-solventQuench BathVitamin EBlock Copolymer Stabilizer

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