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Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
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08:28 min
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September 19, 2017
DOI:
1School of Pharmacy, Tongji Medical College,Huazhong University of Science and Technology, 2Mechanobiology Institute,National University of Singapore, 3Department of Physics,National University of Singapore, 4Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Lab for Soft Functional Materials Research, Department of Physics,Xiamen University, 5Center for Bioimaging Sciences,National University of Singapore
Summary
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A single-molecule magnetic tweezers platform to manipulate G-quadruplexes is reported, which allows for the study of G4 stability and regulation by various proteins.
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You, H., Le, S., Chen, H., Qin, L., Yan, J. Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers. J. Vis. Exp. (127), e56328, doi:10.3791/56328 (2017).
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