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Detection of Copy Number Alterations Using Single Cell Sequencing
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February 17, 2017
DOI:
1Koch Institute for Integrative Cancer Research, Department of Biology,Massachusetts Institute of Technology, 2Howard Hughes Medical Institute, 3Division of Health Sciences and Technology,Harvard Medical School, 4The Barbara K. Ostrom (1978) Bioinformatics and Computing Facility in the Swanson Biotechnology Center, Koch Institute for Integrative Cancer Research,Massachusetts Institute of Technology, 5BioMicro Center, Department of Biology,Massachusetts Institute of Technology
Summary
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Single cell sequencing is an increasingly popular and accessible tool for addressing genomic changes at high resolution. We provide a protocol that uses single cell sequencing to identify copy number alterations in single cells.
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Knouse, K. A., Wu, J., Hendricks, A. Detection of Copy Number Alterations Using Single Cell Sequencing. J. Vis. Exp. (120), e55143, doi:10.3791/55143 (2017).
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