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Elastomeric PGS Scaffolds in Arterial Tissue Engineering
JoVE 杂志
生物工程
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JoVE 杂志 生物工程
Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

DOI:
10.3791/2691-v

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08:35 min

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April 08, 2011

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1Department of Bioengineering,University of Pittsburgh, 2McGowan Institute for Regenerative Medicine,University of Pittsburgh

Chapters

  • 00:05Title
  • 01:00Tubular Scaffold Fabrication, Part 1
  • 03:10Tubular Scaffold Fabrication, Part 2
  • 04:54Scaffold Preparation for Cell Seeding
  • 06:50Cell Seeding, Culture and Tissue Harvesting
  • 07:30Construct Histology
  • 08:15Conclusion

Summary

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Elastomeric PGS scaffolds with vascular smooth muscle cells cultured in a pulsatile flow bioreactor may lead to promising small-diameter arterial constructs with native ECM production in a relatively short culture period.

Tags

Elastomeric PGS ScaffoldsCardiovascular DiseaseMortalityCoronary Artery DiseaseBypass SurgeryAutologous VesselsAllograftsSynthetic GraftsInner Diameter Of ArteriesLimited ApplicationsThrombotic ComplicationsCompliance MismatchLate Intimal HyperplasiaSmall-diameter Arterial ConstructsNonthrombogenicRobustCompliantTri-lamellar StructureMechanical PropertiesBurst PressureCollagen ProductionElastin ProductionComplianceGraft FailureElastomeric BiomaterialMechanical Conditioning

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