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Expanding the Mass Photometry Analysis Concentration Range with Microfluidics

January 26, 2024
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Author Spotlight: Characterization of Low-Affinity Protein Interactions in Solution Using MassFluidix Technology

01:09 min
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Measuring Biomolecular Interactions with Weaker Affinities Using Mass Photometry and Microfluidics

03:29 min
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Analysis of the Microfluidics Coupled Mass Photometry Data to Investigate Low-Affinity Protein-Protein Interactions

02:06 min
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1Refeyn Ltd., 2Adaptix Ltd., 3Physical and Theoretical Chemistry Laboratory, Department of Chemistry,University of Oxford, 4The Kavli Institute for Nanoscience Discovery,University of Oxford

Summary

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This protocol combines mass photometry with a novel microfluidics system to investigate low-affinity protein-protein interactions. This approach is based on the rapid dilution of highly concentrated complexes in solution, which enables low-affinity measurements and broadens the applicability of mass photometry.

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