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NADH Fluorescence Imaging of Isolated Biventricular Working Rabbit Hearts
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Medicine
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JoVE Journal Medicine
NADH Fluorescence Imaging of Isolated Biventricular Working Rabbit Hearts

NADH Fluorescence Imaging of Isolated Biventricular Working Rabbit Hearts

English

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17,594 Views

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12:07 min

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July 24, 2012

DOI:

10.3791/4115-v

DOI:
10.3791/4115-v

•

12:07 min
July 24, 2012

•

6 Views
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1Electrical and Computer Engineering Department,The George Washington University, 2Pharmacology and Physiology Department,The George Washington University

Summary

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The objective is to monitor the mitochondrial redox state of isolated hearts within the context of physiologic preload and afterload pressures. A biventricular working rabbit heart model is presented. High spatiotemporal resolution fluorescence imaging of NADH is used to monitor the mitochondrial redox state of epicardial tissue.

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Cite this Article

Asfour, H., Wengrowski, A. M., Jaimes III, R., Swift, L. M., Kay, M. W. NADH Fluorescence Imaging of Isolated Biventricular Working Rabbit Hearts. J. Vis. Exp. (65), e4115, doi:10.3791/4115 (2012).

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