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Induction of Myocardial Infarction in Adult Zebrafish Using Cryoinjury
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Medicine
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JoVE Journal Medicine
Induction of Myocardial Infarction in Adult Zebrafish Using Cryoinjury

Induction of Myocardial Infarction in Adult Zebrafish Using Cryoinjury

English

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21,526 Views

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11:12 min

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April 18, 2012

DOI:

10.3791/3666-v

DOI:
10.3791/3666-v

•

11:12 min
April 18, 2012

•

16 Views
,
1Department of Biology, Unit of Zoology,University of Fribourg, Fribourg, Switzerland

Summary

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Zebrafish represents a valuable model to study the mechanisms of heart regeneration in vertebrates. Here, we present a protocol for induction of a heart infarct in adult zebrafish using cryoinjury. This method results in massive cell death within 20% of the ventricular wall, similar to that observed in mammalian infarcts.

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Myocardial InfarctionAdult ZebrafishCryoinjuryCardiac RegenerationRegenerative ResponsesAcute InjuriesIschemiaLigationCoronary ArteryVentricular Apex ResectionCryoinjury TechniqueComparative DiscussionInfarctCell DeathCardiomyocytes

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Cite this Article

Chablais, F., Jaźwińska, A. Induction of Myocardial Infarction in Adult Zebrafish Using Cryoinjury. J. Vis. Exp. (62), e3666, doi:10.3791/3666 (2012).

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