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08:40 min
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August 23, 2022
DOI:
1UNC Eshelman School of Pharmacy,University of North Carolina at Chapel Hill, 2Department of Biochemistry & Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences,The University of Melbourne, 3Department of Microbiology & Immunology,University of North Carolina School of Medicine, 4Department of Surgery,University of North Carolina at Chapel Hill, 5Curriculum in Toxicology and Environmental Medicine,University of North Carolina at Chapel Hill, 6Department of Microbiology, Monash Biomedicine Discovery Institute,Monash University
Summary
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熱傷と感染症の臨床シナリオを模倣したモデルは、熱傷研究を促進するために必要です。本プロトコルは、ヒトにおけるそれに匹敵する単純で再現可能なラット熱傷感染モデルを実証する。これにより、新しい局所抗生物質治療を開発するための火傷および火傷後の感染症の研究が容易になります。
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Sharma, R., Yeshwante, S., Vallé, Q., Hussein, M., Thombare, V., McCann, S. M., Maile, R., Li, J., Velkov, T., Rao, G. Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection. J. Vis. Exp. (186), e64345, doi:10.3791/64345 (2022).
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