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Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery
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Medicine
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JoVE Journal Medicine
Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

English

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676 Views

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06:29 min

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October 20, 2023

DOI:

10.3791/64314-v

DOI:
10.3791/64314-v

•

06:29 min
October 20, 2023

•

3 Views
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1Animal Surgery and Resources Core, National Heart, Lung, and Blood Institute,National Institutes of Health, 2College of Veterinary Medicine,Mississippi State University, 3Division of Veterinary Resources, Office of Research Services,National Institutes of Health

Summary

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We describe how to generate a widely used surgical model of intestinal ischemia-reperfusion injury (IRI) in rodents. The procedure involves occlusion of the superior mesenteric artery followed by the restoration of blood flow. This model is useful for studies investigating occlusive causes of intestinal IRI in both veterinary and human medicine.

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Henein, L., Clevenger, R., Keeran, K., Brinster, L. Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery. J. Vis. Exp. (200), e64314, doi:10.3791/64314 (2023).

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