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X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models
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December 09, 2022
DOI:
1Precision Health Program,Michigan State University, 2Department of Radiology,Michigan State University, 3Department of Pharmacology & Toxicology,Michigan State University, 4College of Osteopathic Medicine,Michigan State University, 5TechInsights Inc., 6IQ Advanced Molecular Imaging Facility,Michigan State University, 7Veterinary Diagnostic Laboratory, College of Veterinary Medicine,Michigan State University
Summary
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A procedure for the delivery of a chemical ablative solution to the rat mammary ductal tree for image-guided preventive treatment of breast cancer is described. Mammary epithelial cells can be targeted with minimal collateral tissue damage through cannulation directly into the nipple opening and intraductal infusion of a 70% ethanol-based ablative solution.
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Kenyon, E., Zaluzec, E., Powell, K., Volk, M., Chakravarty, S., Hix, J., Kiupel, M., Shapiro, E. M., Sempere, L. F. X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models. J. Vis. Exp. (190), e64042, doi:10.3791/64042 (2022).
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