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Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
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Neuroscience
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JoVE Journal Neuroscience
Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

DOI:
10.3791/63345-v

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07:57 min

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August 25, 2022

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, , , , , , , ,
1Department of Neurosurgery,University of Kentucky, 2Department of Pediatric Surgery,University of Texas, 3Department of Neurological Surgery,Washington University in St. Louis School of Medicine, 4Department of Orthopedic Surgery,Washington University in St. Louis School of Medicine, 5Department of Pediatrics,Washington University in St. Louis School of Medicine

Chapters

  • 00:04Introduction
  • 01:03Preparation of the Animal for Injection
  • 02:01Setting up the Stereotactic Injector
  • 03:05Animal Injection
  • 04:33MRI Acquisition and Imaging
  • 05:44Results: Induction of Intraventricular Hemorrhage by Hemoglobin Injection
  • 07:20Conclusion

Summary

Automatic Translation

Automatic Translation

We present a model of neonatal intraventricular hemorrhage using rat pups that mimics the pathology seen in humans.

Tags

Neonatal Intraventricular HemorrhageIVHHemoglobin InjectionHydrocephalusBrain InjuryStereotactic InjectionAnimal ModelPathophysiologyPost-hemorrhagic HydrocephalusNeurological Sequelae

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