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Low-Intensity Blast Wave Model for Preclinical Assessment of Closed-Head Mild Traumatic Brain Injury bei Nagetieren
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Neuroscience
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JoVE Journal Neuroscience
Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents
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Low-Intensity Blast Wave Model for Preclinical Assessment of Closed-Head Mild Traumatic Brain Injury bei Nagetieren

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2,492 Views

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06:09 min

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November 06, 2020

DOI:

10.3791/61244-v

DOI:
10.3791/61244-v

•

06:09 min
November 06, 2020

•

27 Views
, , , , , , , ,
1Geriatrics Research Education and Clinical Center,Veterans Affairs, 2Division of Gerontology and Geriatric Medicine,University of Washington, 3Department of Neurosurgery,University of Florida, 4Department of Neurosurgery,West Virginia University, 5Division of Pharmaceutical Sciences,University of Cincinnati, 6Central Illinois Neuro Health Sciences, Bloomington, IL, 7Neuro-research, Dallas, TX

Summary

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Wir stellen hier ein Protokoll eines Blastwellenmodells für Nagetiere vor, um neurobiologische und pathophysiologische Wirkungen von leichten bis mittelschweren traumatischen Hirnverletzungen zu untersuchen. Wir haben ein gasbetriebenes Tisch-Setup etabliert, das mit Drucksensoren ausgestattet ist, die eine zuverlässige und reproduzierbare Erzeugung von blastinduzierten leichten bis mittelschweren traumatischen Hirnverletzungen ermöglichen.

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Cite this Article

Logsdon, A. F., Lucke-Wold, B. P., Turner, R. C., Collins, S. M., Reeder, E. L., Huber, J. D., Rosen, C. L., Robson, M. J., Plattner, F. Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents. J. Vis. Exp. (165), e61244, doi:10.3791/61244 (2020).

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