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دراسة ما قبل تشكيلها فيبريل الناجمة عن تراكم α-Synuclein في الخلايا العصبية الدوبامين الماوس الجنينية الأولية
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Neuroscience
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JoVE Journal Neuroscience
Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
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دراسة ما قبل تشكيلها فيبريل الناجمة عن تراكم α-Synuclein في الخلايا العصبية الدوبامين الماوس الجنينية الأولية

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10:03 min

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August 16, 2020

DOI:

10.3791/61118-v

DOI:
10.3791/61118-v

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10:03 min
August 16, 2020

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1Institute of Biotechnology, HiLIFE,University of Helsinki, 2Neuroscience Center, HiLIFE,University of Helsinki, 3Department of Brain Biochemistry, Maj Institute of Pharmacology,Polish Academy of Sciences

Tags

Alpha-synucleinPreformed FibrilsPrimary Dopamine NeuronsParkinson’s DiseaseNeurodegenerative DiseaseProtein AccumulationCell CultureHigh-throughput ScreeningImage AnalysisNeuron FunctionMolecular Mechanisms

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Er, S., Hlushchuk, I., Airavaara, M., Chmielarz, P., Domanskyi, A. Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons. J. Vis. Exp. (162), e61118, doi:10.3791/61118 (2020).

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