Here we present two easy-to-follow step-by-step protocols for place preference paradigms using optogenetics in mice. Using these two different setups, preference and avoidance behaviors can be solidly assessed within the same apparatus with high spatial and temporal selectivity, and in a straightforward manner.
Bimpisidis, Z., König, N., Wallén-Mackenzie, Å. Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse. J. Vis. Exp. (156), e60867, doi:10.3791/60867 (2020).