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Plataforma de transplante de medula óssea para investigar o papel das células dendríticas na doença enxerto-versus-hospedeiro
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Immunology and Infection
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JoVE Journal Immunology and Infection
Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Plataforma de transplante de medula óssea para investigar o papel das células dendríticas na doença enxerto-versus-hospedeiro

português

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7,604 Views

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08:05 min

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March 17, 2020

DOI:

10.3791/60083-v

DOI:
10.3791/60083-v

•

08:05 min
March 17, 2020

•

2 Views
, , , , , , , ,
1Cancer Division, Burnett School of Biomedical Sciences,University of Central Florida, 2Department of Biochemistry,Hanoi University of Pharmacy, 3Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences,Houston Methodist Research Institute, 4Department of Epidemiology,University of Pittsburgh Graduate School of Public Health, 5Division of Cancer Control and Population Sciences,University of Pittsburgh Medical Center, Hillman Cancer Center

Summary

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A doença enxerto versus hospedeiro é uma grande complicação após o transplante de medula óssea alogênico. As células dendríticas desempenham um papel crítico na patogênese da doença enxerto-versus-hospedeiro. O artigo atual descreve uma nova plataforma de transplante de medula óssea para investigar o papel das células dendríticas no desenvolvimento da doença enxerto versus hospedeiro e o efeito enxerto-versus-leucemia.

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Nguyen, H. D., Huong, P. T., Hossack, K., Gurshaney, S., Ezhakunnel, K., Huynh, T., Alvarez, A. M., Le, N., Luu, H. N. Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease. J. Vis. Exp. (157), e60083, doi:10.3791/60083 (2020).

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