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Adoptive Immuntherapie von iNKT-Zellen in Glucose-6-Phosphat-Isomerase (G6PI)-Induzierte RA-Mäuse
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Immunology and Infection
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JoVE Journal Immunology and Infection
Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
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Adoptive Immuntherapie von iNKT-Zellen in Glucose-6-Phosphat-Isomerase (G6PI)-Induzierte RA-Mäuse

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6,616 Views

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08:43 min

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January 31, 2020

DOI:

10.3791/60048-v

DOI:
10.3791/60048-v

•

08:43 min
January 31, 2020

•

4 Views
, , , , , , , ,
1Medical School of Hebei University, 2Key Laboratory of Pathogenesis Mechanism and Control of Inflammatory-Autoimmune Diseases in Hebei Province

Summary

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Dieses Protokoll verwendet G6PI gemischte Peptide, um rheumatoide Arthritis-Modelle zu konstruieren, die näher an denen der menschlichen rheumatoiden Arthritis in CD4+ T-Zellen und Zytokinen sind. Hochreine invariante natürliche Killer-T-Zellen (hauptsächlich iNKT2) mit spezifischen Phänotypen und Funktionen wurden durch In-vivo-Induktion und In-vitro-Reinigung zur Adoptivimmuntherapie erhalten.

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Adoptive ImmunotherapyINKT CellsGlucose-6-phosphate Isomerase (G6PI)Rheumatoid Arthritis (RA) ModelRA PathogenesisT CellsB CellsInnate ImmunityIn VivoEmulsificationPertussis ToxinSpleenCell IsolationLymphocyte SeparationINKT Cell Purification

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Meng, M., Chen, S., Gao, X., Liu, H., Wang, Y., Zhang, J., Dou, H., Li, W., Chen, D. Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice. J. Vis. Exp. (155), e60048, doi:10.3791/60048 (2020).

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