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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
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Medicine
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JoVE Journal Medicine
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

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7,859 Views

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10:21 min

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August 08, 2019

DOI:

10.3791/59701-v

DOI:
10.3791/59701-v

•

10:21 min
August 08, 2019

•

3 Views
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1Institute of Anatomy,Rostock University Medical Center, 2Department of Nuclear Medicine,Rostock University Medical Center, 3Core Facility Multimodal Small Animal Imaging,Rostock University Medical Center, 4Rudolf-Zenker-Institute for Experimental Surgery,Rostock University Medical Center

Summary

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Here a protocol for continuous blood sampling during PET/CT imaging of rats to measure the arterial input function (AIF) is described. The catheterization, the calibration and setup of the system and the data analysis of the blood radioactivity are demonstrated. The generated data provide input parameters for subsequent bio-kinetic modeling.

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Mann, T., Kurth, J., Möller, A., Förster, J., Vollmar, B., Krause, B. J., Wree, A., Stenzel, J., Lindner, T. Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function. J. Vis. Exp. (150), e59701, doi:10.3791/59701 (2019).

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