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Organoides neuronales humanos para el estudio del cáncer cerebral y las enfermedades neurodegenerativas
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June 28, 2019
DOI:
1Laboratory of Tumor Immunology, Translational Research Center in Onco-Hematology, Department of Internal Medicine Specialties, Faculty of Medicine,University of Geneva, 2Department of Pathology and Immunology, University Medical Center,University of Geneva, 3Laboratory of Toxicology and Therapeutic Drug Monitoring,Geneva University Hospitals, 4Tissue Engineering Laboratory, Hepia/HES-SO,University of Applied Sciences Western Switzerland, 5Laboratory of Experimental cell therapy, Department of Diagnostics,Geneva University Hospitals
Summary
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Este estudio introduce y describe protocolos para derivar dos organoides neuronales humanos específicos como un modelo relevante y preciso para el estudio de 1) desarrollo de glioblastoma humano dentro de organoides neuronales humanos exclusivamente en humanos y 2) neurona dopaminérgica diferenciación que genera un organoide tridimensional.
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Cosset, E., Locatelli, M., Marteyn, A., Lescuyer, P., Dall Antonia, F., Mor, F. M., Preynat-Seauve, O., Stoppini, L., Tieng, V. Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases. J. Vis. Exp. (148), e59682, doi:10.3791/59682 (2019).
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