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A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Dlands: Application to Drug Efficacy Studies
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Medicine
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A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies
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A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Dlands: Application to Drug Efficacy Studies

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11,860 Views

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08:04 min

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January 24, 2020

DOI:

10.3791/59631-v

DOI:
10.3791/59631-v

•

08:04 min
January 24, 2020

•

24 Views
, ,
1Department of Ophthalmology,Stony Brook University, 2Department of Preventive Medicine,Stony Brook University, 3Medicon Pharmaceuticals, Inc.

Summary

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Dieser Artikel beschreibt die Entwicklung einer Methode, um akute oder chronische trockene Augenerkrankungen bei Kaninchen zu induzieren, indem Concanavalin A in alle Teile des Orbital-Tränendrüsensystems injiziert wird. Diese Methode, die den bereits gemeldeten überlegen ist, erzeugt ein reproduzierbares, stabiles Modell des trockenen Auges, das für die Untersuchung pharmakologischer Wirkstoffe geeignet ist.

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Cite this Article

Honkanen, R. A., Huang, L., Rigas, B. A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies. J. Vis. Exp. (155), e59631, doi:10.3791/59631 (2020).

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